Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
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Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clostridium difficile is the main cause of healthcare-associated diarrhoea and its DNA replication mac...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2016
ISSN: 2046-2441
DOI: 10.1098/rsob.160272